- Unique Mucolytic with Antioxidant Properties
- Sugar-free
- Ease of administration, lime-flavoured and convenient dosage
- Effervescent
Fluimucil® A is a unique mucolytic with antioxidant activities. It consists of N – Acetylcysteine (NAC), packaged in sachets (100 mg each) or effervescent tablets (600 mg each). They dissolve easily in water to form orange and lime-flavoured solutions respectively.
How does it work?
N-acetylcysteine (NAC), the active ingredient of Fluimucil® A, exerts an intense mucolytic action on mucous and mucopurulent secretions by depolymerizing the mucoproteic complexes and the nucleic acids that confer viscosity to the vitreous and purulent component of the sputum and of other secretions. Furthermore, NAC exerts a direct antioxidant action, by means of a free thiol (-SH nucleophillic) group, which is able to interact directly with the electophilic groups of the oxidant radicals.
Of particular interest is the recent demonstration that NAC protects α1-antitrypsin, the enzyme inhibitor of elastase, from inactivation due to the action of hypochlorous acid (HOCI), a powerful oxidant agent produced by the myeloperoxidase enzyme of activated phagocytes. These features make Fluimucil® A particularly suitable for the treatment of acute and chronic affections of the respiratory system, characterized by thick and viscous, mucopurulent secretions.
Furthermore, the molecular structure permits the molecule to cross cellular membranes easily. Inside the cell, NAC is deacetylized, forming L-cysteine, an amino acid indispensable for glutathione synthesis (GSH). GSH is a highly reactive tripeptide found ubiquitously in the various tissues of animals and is essential for the maintenance of functional capacity as well as cellular morphological integrity, as it represents the most important protective, endocellular mechanism against oxidant radicals, either of external or internal natural, as well as towards numerous cytotoxic substances.
NAC play a role of primary importance in the maintenance of adequate GSH levels, thus contributing to cellular protection from harmful agents that, through progressive GSH depletion, would be able to express their cytotoxic action, as in the case of acetaminophen poisoning. Due to this mechanism of action, NAC is also indicated as a specific antidote in acetaminophen poisoning, in the course of a cyclophosphamide treatment and in haemorrhagic cystitis, (in the latter case it provides SH groups necessary to inactivate acrolein, a toxic metabolite that affects the urinary mucosae, whilst not interfering with chemotherapy)
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